Size and weight reduction in Holothuria scabra processed as beche-de-mer

Growing demand for beche-de-mer in the marine export market has naturally led to considerable debate among fishery biologists in our country on the problem of irrational exploitation of the natural stock. Along the Tamil Nadu coast Holothuria scabra is fished for beche-de-mer preparation. Studies on the size at first maturity indicated that the spawning size is 201-230 mm and this size group after processing attains a reduced size of 73-80 mm. Revival of the natural stock can take place and this would help in encountering specimens beyond the size of 75 mm in length. More studies are required on the biology of Holothurians to determine precisely the period of maturity and spawning in different species in a year and it is advisable to observe a 'closed season' each year to conserve the holothurian resources

Study on Durability Characteristics of Self - Compacting Concrete with Fly Ash

This paper investigates the study of workability and durability characteristics of Self-Compacting Concrete (SCC) with Viscosity Modifying Admixture (VMA), and containing Class F fly ash. The mix design for SCC was arrived as per the Guidelines of European Federation of National Associations Representing for Concrete (EFNARC). In this investigation, SCC was made by usual ingredients such as cement, fine aggregate, coarse aggregate, water and mineral admixture fly ash at various replacement levels (10%, 20%, 30%, 40% and 50%). The super plasticizer used was Glenium B233 and the viscosity modifying agent used was Glenium Stream 2. The experiments are carried out by adopting a water-powder ratio of 0.45. Workability of the fresh concrete is determined by using tests such as: slump flow, T50, V-funnel, L-Box and U-box tests. The durability of concrete is tested by acid resistance, sulphate attack and saturated water absorption at the age of 28, 56 and 90 days

Analysis of cutaneous adverse drug reactions in a tertiary care hospital in South Tamil Nadu

Background: Cutaneous adverse drug reactions (CADRs) are among the most frequently reported adverse drug reactions (10 to 30%) with overall incidence of 6.2/1000 cases in India and 8% of hospitalisation among Dermatology inpatients. The aim was to analyse the CADRs with reference to its prevalence, causative drugs, morphological patterns, polypharmacy and drug reaction severity by Hartwig’s severity assessment scale.Methods: This study was a retrospective study done in the Department of Dermatology, Venereology and Leprosy (DVL) over a period of 5 years (2015 to 2019) from CADR registers. Mean, standard deviation and chi square test were used for statistical analysis. P≤0.05 was considered as statistically significant.Results: A total of 134 cases of CADRs were encountered which comprised 0.2% (2/1000) of total OP census with equal gender ratio and involved most commonly the younger adults. The drug groups mainly responsible were anticonvulsants (24.7%) followed by non-steroidal anti-inflammatory drugs (NSAIDS) (22.5%), antibiotics (20.9%) followed by antiretrovirals (ART) and antituberculous drugs (ATT). The common morphological patterns were acute exanthem (32.2%), exfoliative dermatitis (14.9%) and toxic epidermal necrolysis (14.2%). Over the counter drugs accounted for 25.6% of cases. Around 38.1% were on polypharmacy. In this study, 15.7% had mild CADR, 53.7% had moderate and 30.6% had severe drug reactions with 2.2% mortality based on the Hartwig’s severity assessment scale. Commonest cause of severe CADRs was anticonvulsants and benign CADRs was NSAIDS.Conclusions: Proper history taking and documentation of data, recollection of sequence of events by the patient and drug re-challenge will help us in deciding the causative drug preventing further occurrence

TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosis.

TNFα-related apoptosis-inducing ligand (TRAIL), specifically initiates programmed cell death, but often fails to eradicate all cells, making it an ineffective therapy for cancer. This fractional killing is linked to cellular variation that bulk assays cannot capture. Here, we quantify the diversity in cellular signaling responses to TRAIL, linking it to apoptotic frequency across numerous cell systems with single-cell mass cytometry (CyTOF). Although all cells respond to TRAIL, a variable fraction persists without apoptotic progression. This cell-specific behavior is nonheritable where both the TRAIL-induced signaling responses and frequency of apoptotic resistance remain unaffected by prior exposure. The diversity of signaling states upon exposure is correlated to TRAIL resistance. Concomitantly, constricting the variation in signaling response with kinase inhibitors proportionally decreases TRAIL resistance. Simultaneously, TRAIL-induced de novo translation in resistant cells, when blocked by cycloheximide, abrogated all TRAIL resistance. This work highlights how cell signaling diversity, and subsequent translation response, relates to nonheritable fractional escape from TRAIL-induced apoptosis. This refined view of TRAIL resistance provides new avenues to study death ligands in general

Performance Comparisons of Routing Protocols in Mobile Ad Hoc Networks

Mobile Ad hoc Network (MANET) is a collection of wireless mobile nodes that dynamically form a network temporarily without any support of central administration. Moreover, Every node in MANET moves arbitrarily making the multi-hop network topology to change randomly at unpredictable times. There are several familiar routing protocols like DSDV, AODV, DSR, etc...which have been proposed for providing communication among all the nodes in the network. This paper presents a performance comparison of proactive and reactive protocols DSDV, AODV and DSR based on metrics such as throughput, packet delivery ratio and average end-to-end delay by using the NS-2 simulator.Comment: 9 Pages,10 Figures, 3 Table

An Improving Genetic Programming Approach Based Deduplication Using KFINDMR

Abstract-The record deduplication is the task of identifying, in a data repository, records that refer to the same real world entity or object in spite of misspelling words, types, different writing styles or even different schema representations or data types. In existing system aims at providing Unsupervised Duplication Detection (UDD) method which can be used to identify and remove the duplicate records from different data sources. Starting from the non duplicate set, the two cooperating classifiers, a Weighted Component Similarity Summing Classifier (WCSS) and Support Vector Machine (SVM) are used to iteratively identify the duplicate records from the non duplicate record and present a genetic programming (GP) approach to record deduplication. Their GP-based approach is also able to automatically find effective deduplication functions. The genetic programming approach is time consuming task so we propose new algorithm KFINDMR (KFIND using Most Represented data samples) to find the most represented data samples to improve the accuracy of the classifier. The proposed system calculates the mean value of the most represented data samples in centroid of the record members; it selects the first most represented data sample that closest to the mean value calculates the minimum distance. The system Remove the duplicate dataset samples in the system and find the optimization solution to deduplication of records or data samples

Dependence of recombination mechanisms and strength on processing conditions in polymer solar cells

Charge carrier recombination due to carrier trapping is not often considered in polymer based solar cells, except in those using non-fullerene acceptors or new donor polymers with limited short-range order. However, we show that even for the canonical poly(3-hexylthiophene): phenyl-C61-butyric acid methyl ester (P3HT:PCBM) system, relative strengths of bimolecular and trap-assisted recombination are strongly dependent on processing conditions. For slow-grown active-layers, bimolecular recombination is indeed the major loss mechanism under one sun illumination. However, for fast-grown active-layers, trap-assisted recombination dominates over bimolecular recombination by an order of magnitude, and recombination strength at short-circuit condition is 3-4 times higher, leading to loss of photocurrent and lowering of fill factor